Edwin Severin Iversen

Edwin Severin Iversen

Research Professor of Statistical Science

External address: 
211E Old Chem, Durham, NC 27708
Internal office address: 
Box 90251, Durham, NC 27708-0251
(919) 681-8442


Bayesian statistical modeling with application to problems in genetic
epidemiology and cancer research; models for epidemiological risk
assessment, including hierarchical methods for combining related
epidemiological studies; ascertainment corrections for high risk
family data; analysis of high-throughput genomic data sets.

Education & Training

  • Ph.D., Yale University 1995

  • M.S., University of Chicago 1989

  • B.S., University of Chicago 1987

Selected Grants

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Biodosimetry High-Throughput Test awarded by DxTerity Diagnostics (Co Investigator). 2017 to 2019

Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors awarded by MD Anderson Cancer Center (Co Investigator). 2016 to 2019

OC3 Subtype-Specific Risk Model awarded by H. Lee Moffitt Cancer Center & Research Institute (Principal Investigator). 2018

Early child care and risk of obesity awarded by Johns Hopkins University - School of Public Health (Co Investigator). 2015 to 2018

BRCA 1 and BRCA2 missense mutations and breast cancer risk awarded by Mayo Clinic (Principal Investigator). 2013 to 2018

Early child care and risk of obesity awarded by National Institutes of Health (Co Investigator). 2012 to 2017

Epidemiologic factors and survival by molecular subtypes of ovarian cancer awarded by Fred Hutchinson Cancer Research Center (Principal Investigator). 2015 to 2017

Epidemiologic factors and survival by molecular subtypes of ovarian cancer awarded by Fred Hutchinson Cancer Research Center (Co Investigator). 2013 to 2017

Nitrosative Stress and Symptoms During Childhood Leukemia Treatment awarded by Alex's Lemonade Stand (Statistician). 2014 to 2017


Clydec, M, and Iversen, ES. "Bayesian model averaging in the M-open framework." Bayesian Theory and Applications.: Oxford University Press. January 24, 2013. 483-498. Full Text Open Access Copy

Fernandes, VC, Golubeva, VA, Di Pietro, G, Shields, C, Amankwah, K, Nepomuceno, TC, de Gregoriis, G, Abreu, RBV, Harro, C, Gomes, TT, Silva, RF, Suarez-Kurtz, G, Couch, F, Iversen, ES, Monteiro, ANA, and Carvalho, MA. "Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation." The Journal of Biological Chemistry (February 14, 2019). Full Text

Buckley, MA, Woods, NT, Tyrer, JP, Mendoza-Fandiño, G, Lawrenson, K, Hazelett, DJ, Najafabadi, HS, Gjyshi, A, Carvalho, RS, Lyra, PC, Coetzee, SG, Shen, HC, Yang, AW, Earp, MA, Yoder, SJ, Risch, H, Chenevix-Trench, G, Ramus, SJ, Phelan, CM, Coetzee, GA, Noushmehr, H, Hughes, TR, Sellers, TA, Goode, EL, Pharoah, PD, Gayther, SA, Monteiro, ANA, and Ovarian Cancer Association Consortium, . "Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus." Cancer Research 79.3 (February 2019): 467-481. Full Text

Iversen, ES, McCarthy, JM, Bell Burdett, K, Lipton, G, Phillips, G, Dressman, H, Ross, J, and Chao, N. "Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans." International Journal of Radiation Biology (October 29, 2018): 1-10. Full Text

Kelemen, LE, Earp, M, Fridley, BL, Chenevix-Trench, G, Australian Ovarian Cancer Study Group, , Fasching, PA, Beckmann, MW, Ekici, AB, Hein, A, Lambrechts, D, Lambrechts, S, Van Nieuwenhuysen, E, Vergote, I, Rossing, MA, Doherty, JA, Chang-Claude, J, Behrens, S, Moysich, KB, Cannioto, R, Lele, S, Odunsi, K, Goodman, MT, Shvetsov, YB, Thompson, PJ, Wilkens, LR, Dörk, T, Antonenkova, N, Bogdanova, N, Hillemanns, P, Runnebaum, IB, du Bois, A, Harter, P, Heitz, F, Schwaab, I, Butzow, R, Pelttari, LM, Nevanlinna, H, Modugno, F, Edwards, RP, Kelley, JL, Ness, RB, Karlan, BY, Lester, J, Orsulic, S, Walsh, C, Kjaer, SK, Jensen, A, Cunningham, JM, Vierkant, RA, Giles, GG, Bruinsma, F, Southey, MC, Hildebrandt, MAT, Liang, D, Lu, K, Wu, X, Sellers, TA, Levine, DA, Schildkraut, JM, Iversen, ES, Terry, KL, Cramer, DW, Tworoger, SS, Poole, EM, Bandera, EV, Olson, SH, Orlow, I, Vestrheim Thomsen, LC, Bjorge, L, Krakstad, C, Tangen, IL, Kiemeney, LA, Aben, KKH, Massuger, LFAG, van Altena, AM, Pejovic, T, Bean, Y, Kellar, M, Cook, LS, Le, ND, Brooks-Wilson, A, Gronwald, J, Cybulski, C, Jakubowska, A, Lubiński, J, Wentzensen, N, Brinton, LA, Lissowska, J, Hogdall, E, Engelholm, SA, Hogdall, C, Lundvall, L, Nedergaard, L, Pharoah, PDP, Dicks, E, Song, H, Tyrer, JP, McNeish, I, Siddiqui, N, Carty, K, Glasspool, R, Paul, J, Campbell, IG, Eccles, D, Whittemore, AS, McGuire, V, Rothstein, JH, Sieh, W, Narod, SA, Phelan, CM, McLaughlin, JR, Risch, HA, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Gentry-Maharaj, A, Ramus, SJ, Wu, AH, Pearce, CL, Lee, AW, Pike, MC, Kupryjanczyk, J, Podgorska, A, Plisiecka-Halasa, J, Sawicki, W, Goode, EL, Berchuck, A, and Ovarian Cancer Association Consortium, . "rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology." International Journal of Molecular Sciences 19.9 (August 21, 2018). Full Text

Jim, HSL, Lin, H-Y, Tyrer, JP, Lawrenson, K, Dennis, J, Chornokur, G, Chen, Z, Chen, AY, Permuth-Wey, J, Aben, KK, Anton-Culver, H, Antonenkova, N, Bruinsma, F, Bandera, EV, Bean, YT, Beckmann, MW, Bisogna, M, Bjorge, L, Bogdanova, N, Brinton, LA, Brooks-Wilson, A, Bunker, CH, Butzow, R, Campbell, IG, Carty, K, Chang-Claude, J, Cook, LS, Cramer, DW, Cunningham, JM, Cybulski, C, Dansonka-Mieszkowska, A, du Bois, A, Despierre, E, Sieh, W, Doherty, JA, Dörk, T, Dürst, M, Easton, DF, and Eccles, DM et al. "Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)." Journal of genetics and genome research 2.2 (January 2015).

Raska, P, Iversen, ES, Chen, A, Chen, Z, Fridley, BL, Permuth-Wey, J, Tsai, Y-Y, Vierkant, RA, Goode, EL, Risch, H, Schildkraut, JM, Sellers, TA, and Barnholtz-Sloan, J. "Abstract 1678: European ancestry and ovarian cancer: Testing for their association using case control data." Cancer Research 72.8 Supplement (April 15, 2012): 1678-1678. Full Text

Pearce, CL, Near, AM, Van Den Berg, DJ, Ramus, SJ, Gentry-Maharaj, A, Menon, U, Gayther, SA, Anderson, AR, Edlund, CK, Wu, AH, Chen, X, Beesley, J, Webb, PM, Holt, SK, Chen, C, Doherty, JA, Rossing, MA, Whittemore, AS, McGuire, V, DiCioccio, RA, Goodman, MT, Lurie, G, Carney, ME, Wilkens, LR, Ness, RB, Moysich, KB, Edwards, R, Jennison, E, Kjaer, SK, Hogdall, E, Hogdall, CK, Goode, EL, Sellers, TA, Vierkant, RA, Cunningham, JC, Schildkraut, JM, Berchuck, A, Moorman, PG, Iversen, ES, Cramer, DW, Terry, KL, Vitonis, AF, Titus-Ernstoff, L, Song, H, Pharoah, PDP, Spurdle, AB, Anton-Culver, H, Ziogas, A, Brewster, W, Galitovskiy, V, and Chenevix-Trench, G. "Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium." British Journal of Cancer 100.2 (January 2009): 412-420. Full Text

Moorman, PG, Schildkraut, JM, Myers, ER, Iversen, ES, Warren-White, N, and Wang, F. "Weight gain after pre-menopausal hysterectomy." June 1, 2008.

Berchuck, A, Lancaster, JM, Iversen, ES, Luo, J, Levine, DA, Boyd, J, Secord, AA, Marks, JR, Nevins, JR, and Dressman, H. "Most early-stage serous ovarian cancers have gene expression profiles predictive of long-term survival." March 2007.