Edwin Severin Iversen

Edwin Severin Iversen

Research Professor of Statistical Science

External address: 
211E Old Chem, Durham, NC 27708
Internal office address: 
Box 90251, Durham, NC 27708-0251
(919) 681-8442


Bayesian statistical modeling with application to problems in genetic
epidemiology and cancer research; models for epidemiological risk
assessment, including hierarchical methods for combining related
epidemiological studies; ascertainment corrections for high risk
family data; analysis of high-throughput genomic data sets.

Education & Training

  • Ph.D., Yale University 1995

  • M.S., University of Chicago 1989

  • B.S., University of Chicago 1987

Selected Grants

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

OC3 Subtype-Specific Risk Model awarded by H. Lee Moffitt Cancer Center & Research Institute (Principal Investigator). 2018

Biodosimetry High-Throughput Test awarded by DxTerity Diagnostics (Co Investigator). 2017 to 2018

Early child care and risk of obesity awarded by Johns Hopkins University - School of Public Health (Co Investigator). 2015 to 2018

BRCA 1 and BRCA2 missense mutations and breast cancer risk awarded by Mayo Clinic (Principal Investigator). 2013 to 2018

Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors awarded by MD Anderson Cancer Center (Co Investigator). 2016 to 2017

Epidemiologic factors and survival by molecular subtypes of ovarian cancer awarded by Fred Hutchinson Cancer Research Center (Principal Investigator). 2015 to 2017

Epidemiologic factors and survival by molecular subtypes of ovarian cancer awarded by Fred Hutchinson Cancer Research Center (Co Investigator). 2013 to 2017

Nitrosative Stress and Symptoms During Childhood Leukemia Treatment awarded by Alex's Lemonade Stand (Statistician). 2014 to 2017

Atlantic Breast and Gynecologic Clinical Validation Center awarded by National Institutes of Health (Statistical Programmer). 1999 to 2016


Guidugli, L, Shimelis, H, Masica, DL, Pankratz, VS, Lipton, GB, Singh, N, Hu, C, Monteiro, ANA, Lindor, NM, Goldgar, DE, Karchin, R, Iversen, ES, and Couch, FJ. "Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches." American journal of human genetics (January 17, 2018). Full Text

Phelan, CM, Kuchenbaecker, KB, Tyrer, JP, Kar, SP, Lawrenson, K, Winham, SJ, Dennis, J, Pirie, A, Riggan, MJ, Chornokur, G, Earp, MA, Lyra, PC, Lee, JM, Coetzee, S, Beesley, J, McGuffog, L, Soucy, P, Dicks, E, Lee, A, Barrowdale, D, Lecarpentier, J, Leslie, G, Aalfs, CM, Aben, KKH, Adams, M, Adlard, J, Andrulis, IL, Anton-Culver, H, Antonenkova, N, AOCS study group, , Aravantinos, G, Arnold, N, Arun, BK, Arver, B, Azzollini, J, Balmaña, J, Banerjee, SN, Barjhoux, L, Barkardottir, RB, and Bean, Y et al. "Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer." Nature genetics 49.5 (May 2017): 680-691. Full Text

Sosa-Pagán, JO, Iversen, ES, and Grandl, J. "TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity." Scientific reports 7.1 (April 3, 2017): 549-. Full Text

Benjamin Neelon, SE, Østbye, T, Bennett, GG, Kravitz, RM, Clancy, SM, Stroo, M, Iversen, E, and Hoyo, C. "Cohort profile for the Nurture Observational Study examining associations of multiple caregivers on infant growth in the Southeastern USA." BMJ open 7.2 (February 8, 2017): e013939-. Full Text

Mayhew, MB, Iversen, ES, and Hartemink, AJ. "Characterization of dependencies between growth and division in budding yeast." Journal of the Royal Society, Interface 14.127 (February 2017). Full Text

Southey, MC, Goldgar, DE, Winqvist, R, Pylkäs, K, Couch, F, Tischkowitz, M, Foulkes, WD, Dennis, J, Michailidou, K, van Rensburg, EJ, Heikkinen, T, Nevanlinna, H, Hopper, JL, Dörk, T, Claes, KB, Reis-Filho, J, Teo, ZL, Radice, P, Catucci, I, Peterlongo, P, Tsimiklis, H, Odefrey, FA, Dowty, JG, Schmidt, MK, Broeks, A, Hogervorst, FB, Verhoef, S, Carpenter, J, Clarke, C, Scott, RJ, Fasching, PA, Haeberle, L, Ekici, AB, Beckmann, MW, Peto, J, Dos-Santos-Silva, I, Fletcher, O, Johnson, N, and Bolla, MK et al. "PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS." Journal of medical genetics 53.12 (December 2016): 800-811. Full Text

Zhang, Y, Nault, I, Mitran, S, Iversen, ES, and Zhong, P. "Effects of Stone Size on the Comminution Process and Efficiency in Shock Wave Lithotripsy." Ultrasound in medicine & biology 42.11 (November 2016): 2662-2675. Full Text

Clyde, MA, Palmieri Weber, R, Iversen, ES, Poole, EM, Doherty, JA, Goodman, MT, Ness, RB, Risch, HA, Rossing, MA, Terry, KL, Wentzensen, N, Whittemore, AS, Anton-Culver, H, Bandera, EV, Berchuck, A, Carney, ME, Cramer, DW, Cunningham, JM, Cushing-Haugen, KL, Edwards, RP, Fridley, BL, Goode, EL, Lurie, G, McGuire, V, Modugno, F, Moysich, KB, Olson, SH, Pearce, CL, Pike, MC, Rothstein, JH, Sellers, TA, Sieh, W, Stram, D, Thompson, PJ, Vierkant, RA, Wicklund, KG, Wu, AH, Ziogas, A, and Tworoger, SS et al. "Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci." American journal of epidemiology 184.8 (October 3, 2016): 579-589. Full Text Open Access Copy

Hampras, SS, Sucheston-Campbell, LE, Cannioto, R, Chang-Claude, J, Modugno, F, Dörk, T, Hillemanns, P, Preus, L, Knutson, KL, Wallace, PK, Hong, C-C, Friel, G, Davis, W, Nesline, M, Pearce, CL, Kelemen, LE, Goodman, MT, Bandera, EV, Terry, KL, Schoof, N, Eng, KH, Clay, A, Singh, PK, Joseph, JM, Aben, KKH, Anton-Culver, H, Antonenkova, N, Baker, H, Bean, Y, Beckmann, MW, Bisogna, M, Bjorge, L, Bogdanova, N, Brinton, LA, Brooks-Wilson, A, Bruinsma, F, Butzow, R, Campbell, IG, Carty, K, and Cook, LS et al. "Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer." Oncotarget 7.43 (October 2016): 69097-69110. Full Text

Permuth, JB, Pirie, A, Ann Chen, Y, Lin, H-Y, Reid, BM, Chen, Z, Monteiro, A, Dennis, J, Mendoza-Fandino, G, AOCS Study Group, , Australian Cancer Study (Ovarian Cancer), , Anton-Culver, H, Bandera, EV, Bisogna, M, Brinton, L, Brooks-Wilson, A, Carney, ME, Chenevix-Trench, G, Cook, LS, Cramer, DW, Cunningham, JM, Cybulski, C, D'Aloisio, AA, Anne Doherty, J, Earp, M, Edwards, RP, Fridley, BL, Gayther, SA, Gentry-Maharaj, A, Goodman, MT, Gronwald, J, Hogdall, E, Iversen, ES, and Jakubowska, A et al. "Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk." Human molecular genetics 25.16 (August 2016): 3600-3612. Full Text


Andrew, B, Iversen, ES, Lancaster, JM, Dressman, HK, West, M, Nevins, JR, Marks, JR, and Miller, BE. "Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays." Women's Oncology Review 4.3 (2004): 203-204. Full Text