Eigenvalues in multivariate random effects models

Zhou Fan, Stanford

Wednesday, January 17, 2018 - 3:30pm

Random effects models are commonly used to measure genetic variance-covariance matrices of quantitative phenotypic traits in a population. The eigenvalues of these matrices describe the evolutionary response of the population to selection. However, they may be difficult to estimate from limited samples when the number of traits is large. I will discuss several phenomena concerning the eigenvalues of classical MANOVA estimators in such high-dimensional settings, including dispersion of the bulk eigenvalue distribution, bias and aliasing of large "spike" eigenvalues, and Tracy-Widom limits at the spectral edges. I will then describe a new statistical procedure that uses these results to consistently estimate the large population eigenvalues in a high-dimensional regime. The proofs develop and extend techniques in random matrix theory and free probability, which I will also briefly describe.

This is joint work with Iain M. Johnstone, Yi Sun, Mark W. Blows, and Emma Hine.

Seminars generally take place in 116 Old Chemistry Building on Fridays from 3:30 - 4:30 pm. For additional information contact: karen.whitesell@duke.edu or phone 919-684-8029. Sorry, but we do not have reprints available. Please feel free to contact the authors by email for follow-up information, articles, etc. Reception following seminar in 211 Old Chemistry

Old Chemistry 116

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