Chi Wei Cliburn Chan

Associate Professor of Biostatistics and Bioinformatics

External address: 
2424 Erwin Road Ste 1102, 11078 Hock Plaza Duke Box 2721, Durham, NC 27705
Internal office address: 
Duke Box 2721, Durham, NC 27710
Phone: 
(919) 668-2459

Overview

Computational immunology (stochastic and spatial models and simulations, T cell signaling, immune regulation)
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)

Education & Training

  • Ph.D., University College of London 2002

  • M.S., University College of London 1998

  • B.S., University of London (UK) 1997

  • M.B.B.S., National University of Singapore 1991

EQAPOL - Years 2017 to 2024 - BASE awarded by National Institutes of Health (Biostatistician). 2017 to 2024

Consequences of marijuana use on inflammatory pathways in HIV-infected youth awarded by National Institutes of Health (Co Investigator). 2017 to 2022

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Senior Statistician). 2017 to 2022

A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Adjuvant Discovery Program (Option #2) awarded by National Institutes of Health (Statistician). 2014 to 2019

Immunological biomarker studies in myasthenia gravis awarded by National Institutes of Health (Advisor). 2014 to 2019

Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation awarded by Foundation for Anesthesia Education and Research (Biostatistician). 2017 to 2019

A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health (Co-Principal Investigator). 2016 to 2019

Molecular Atlas of Lung Development - Data Coordinating Center awarded by National Institutes of Health (Co Investigator). 2014 to 2019

Pages

Gouttefangeas, C, Chan, C, Attig, S, Køllgaard, TT, Rammensee, H-G, Stevanović, S, Wernet, D, thor Straten, P, Welters, MJP, Ottensmeier, C, van der Burg, SH, and Britten, CM. "Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters." Cancer Immunology, Immunotherapy 64.5 (May 2015): 585-598. Full Text

Gouttefangeas, C, Walter, S, Welters, MJP, Ottensmeier, C, Burg, SHVD, Britten, CM, and Chan, C. "Flow cytometry in cancer immunotherapy: Applications, quality assurance, and future." Cancer Immunology: A Translational Medicine Context (2015): 471-490. Full Text

Richards, AJ, Staats, J, Enzor, J, McKinnon, K, Frelinger, J, Denny, TN, Weinhold, KJ, and Chan, C. "Setting objective thresholds for rare event detection in flow cytometry." Journal of immunological methods 409 (July 2014): 54-61. Full Text Open Access Copy

Staats, JS, Enzor, JH, Sanchez, AM, Rountree, W, Chan, C, Jaimes, M, Chan, RC-F, Gaur, A, Denny, TN, and Weinhold, KJ. "Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays." Journal of immunological methods 409 (July 2014): 44-53. Full Text Open Access Copy

Nair, SK, Tomaras, GD, Sales, AP, Boczkowski, D, Chan, C, Plonk, K, Cai, Y, Dannull, J, Kepler, TB, Pruitt, SK, and Weinhold, KJ. "High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes." Scientific reports 4 (April 23, 2014): 4632-. Full Text

Staats, JS, Enzor, JH, Sanchez, AM, Rountree, W, Chan, C, Jaimes, M, Chan, RCF, Gaur, A, Denny, TN, and Weinhold, KJ. "Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays." Journal of Immunological Methods 409 (January 1, 2014): 44-53. (Review) Full Text Open Access Copy

Richards, AJ, Staats, J, Enzor, J, McKinnon, K, Frelinger, J, Denny, TN, Weinhold, KJ, and Chan, C. "Setting objective thresholds for rare event detection in flow cytometry." Journal of Immunological Methods 409 (January 1, 2014): 54-61. Full Text Open Access Copy

Shetty, G, Beasley, GM, Sparks, S, Barfield, M, Masoud, M, Mosca, PJ, Pruitt, SK, Salama, AKS, Chan, C, Tyler, DS, and Weinhold, KJ. "Plasma cytokine analysis in patients with advanced extremity melanoma undergoing isolated limb infusion." Ann Surg Oncol 20.4 (April 2013): 1128-1135. Full Text

Aghaeepour, N, Finak, G, Hoos, H, Mosmann, TR, Brinkman, R, Gottardo, R, Scheuermann, RH, Dougall, D, Khodabakhshi, AH, Mah, P, Obermoser, G, Spidlen, J, Taylor, I, Wuensch, SA, Bramson, J, Eaves, C, Weng, AP, Fortuno, ES, Ho, K, Kollmann, TR, Rogers, W, De Rosa, S, Dalai, B, Azad, A, Pothen, A, Brandes, A, Bretschneider, H, Bruggner, R, Finck, R, Jia, R, Zimmerman, N, Linderman, M, Dill, D, Nolan, G, Chan, C, Khettabi, FE, O'Neill, K, Chikina, M, Ge, Y, Sealfon, S, Sugár, I, and Gupta, A et al. "Critical assessment of automated flow cytometry data analysis techniques." Nature Methods 10.3 (March 1, 2013): 228-238. Full Text

Chan, C, Billard, M, Ramirez, SA, Schmidl, H, Monson, E, and Kepler, TB. "A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields." Bulletin of mathematical biology 75.1 (January 8, 2013): 185-205. Full Text

Pages

Kvistborg, P, Gouttefangeas, C, Aghaeepour, N, Cazaly, A, Chattopadhyay, PK, Chan, C, Eckl, J, Finak, G, Hadrup, SR, Maecker, HT, Maurer, D, Mosmann, T, Qiu, P, Scheuermann, RH, Welters, MJP, Ferrari, G, Brinkman, RR, and Britten, CM. "Thinking outside the gate: single-cell assessments in multiple dimensions." Immunity 42.4 (April 2015): 591-592. (Letter) Full Text