Statistical Methods in Bioinformatics

Statistical and analytical tools for bioinformatics and genomics. Methods for comparison, database search, and functional inference for DNA, RNA, and protein sequences; analysis of families of molecular sequences and structures; inference in genetic pedigrees and basic linkage analysis; analysis of gene expression experiments. Topics include: sequence comparison algorithms and Karlin-Altschul statistics; Hidden Markov models of families; statistics of protein structure threading; visualization and comparative analyses for oligonucleotide array datasets.